Diane's sister, Elaine, is in town and as Wayne doesn't like her he invents something so he can't understand her. As usual Wayne's creation goes wrong and Elaine's personality gets into Wayne's brain. Now the family must work together to get everything back to normal without the help of Wayne.

Wayne is busy trying to perfect his Hypolyptical Organic Oxide Ray (a.k.a. the Hoo-Ray), a device based on mood-ring technology that will cause people to be happy, thus ending war and boosting global self-esteem. Wayne's new foreign assistant, Vlad Bolvahnicz, cautions that changing nature isn't necessarily a good thing.While working late on the project, Vlad is visited by members of the Global League of Oppressed Madmen (GLOOM). Vlad is actually an anarchist too, and his job at Jentech is part of GLOOM's eco-terrorist plot to teach the industrialized, polluting Western hemisphere a lesson by destroying a key polluter city.