When Godzilla is accused of attacking New York, the military call in H.E.A.T. to help contain him. But Phillipe Roache has returned from France... with orders to terminate Godzilla. However, H.E.A.T. discover the real culprit is a hideous mutation called the Chameleon, genetically engineered by Cameron Winter (who has escaped from jail) to frame Godzilla. Can they stop Winter and reveal the truth before it's too late?

Acting on confidential information from Phillipe, H.E.A.T. investigate an abandoned lab in the Amazon jungle, where 50 years before, French scientists succeeded in creating a creature made of pure DNA. The creature is capable of mimicking the shape of any living creature it touches, and soon the team are put on edge, uncertain who to trust. They must find a way to aid Godzilla and destroy the creature before it can reproduce and go on to create a new master race of monsters.