Jon Karl has the latest on former Pres. Biden's health after a spokesman revealed Biden last got a PSA test for prostate cancer in 2014; Martha Raddatz has details on Pres. Trump unveiling plans for a massive missile shield defense system called the "Golden Dome," using interceptor technology on the ground and in space, which could cost more than $175 billion; as Israel expands its assault in Gaza, Ian Pannell has the latest on the United Nations' warning that 14,000 babies will die in the next 48 hours if aid doesn't reach them now; and more on tonight's broadcast of World News Tonight with David Muir.

Trevor Ault has the latest on the investigation into the small plane that crashed in a sleeping San Diego neighborhood in the middle of the night, killing at least two people; Pierre Thomas has details on the two Israeli embassy staff members that were killed outside D.C.'s Capital Jewish Museum in what the FBI is calling a "targeted, antisemitic" attack; as a rare, late-season nor'easter threatens to disrupt record holiday travel for millions with heavy rain and winds of up to 50 mph, Matt Rivers reports from Newark Airport, and Lee Goldberg has the Memorial Day weekend forecast; and more on tonight's broadcast of World News Tonight with David Muir.