As Trump's latest tariffs take effect, Jay O'Brien reports on the massive demonstrations across the U.S. as protesters rally against the president's policies and Elon Musk; Morgan Norwood reports from Arkansas where life-threatening storms — for the fourth day — have unleashed floods that are swamping roads and stranding motorists; the IDF says it will investigate after a newly released video appeared to show aid workers and first responders being fired upon by Israeli soldiers in Gaza; and more on tonight's broadcast of World News Tonight with David Muir.

Market turmoil and Trump's new tariff threats to China; Biotech lab: Extinct dire wolf created using grey wolf genes; Trump says he will hold direct talks with Iran on its nuclear program.