Blake Shelton, Gwen Stefani, OneRepublic, Ellie Goulding, Steve Martin and the Steep Canyon Rangers, Sam Smith, James Taylor, Meghan Trainor and Adrienne Warren (the star of "Tina: The Tina Turner Musical") will perform.

In addition to the music performances, Jim Gaffigan, Tony Hale, Ray Romano and Lilly Singh will also showcase their comedic stylings. Film and TV favorites Bryan Cranston, Mario Lopez, Milo Ventimiglia and Noah Jupe will make appearances throughout the evening.

In addition to the unforgettable performances and original sketches, viewers will also see short compelling films that show how donations to Red Nose Day are used to change and save the lives of children in need in the U.S. and in some of the most underserved communities around the world.

In light of the health crisis and in an effort to help the public adhere to current health recommendations to avoid face-touching, Red Nose Day's iconic Red Noses will not be sold in Walgreens stores this year. Instead Red Nose Day and Walgreens teamed up to create this year's new digital Red Nose which offers an easy, fun way for the public to participate in the annual campaign, even while staying at home.