Jac and Matteo's relationship is still fraught following Jac's shocking discovery. However, when Jac and Matteo bump heads over a pioneering procedure, it becomes clear that they need to stop the personal encroaching on the professional - but has the rot already set in? Following on from Sacha's recent health scare, it becomes clear to Essie that he's at a low ebb. But when Sacha puts himself in a difficult situation, Essie is the only one he can turn to. Can he muster up enough bravery to ask for the help he needs? Ric is determined to run AAU like a tight ship, but just as he begins to get things in order, a shock guest sends him into a tailspin.

Matteo wants to prove his marriage is over, but a face from the past brings up painful memories of his life before Holby. Dominic struggles with his first day back on Keller when a deceitful patient reminds him of his traumatic relationship with Isaac. When Bernie's son Cameron returns, Morven must finally confront her feelings for him.