As the newly appointed director of nursing, Fletch learns that with great power comes great responsibility. Essie must close the door on a very important chapter in her life, but is she ready to let go? Donna gets herself into some hot water.

Nina receives surprising news that throws her entire future with estranged husband Matteo into question. While trying to rally morale on a despondent Keller, Nina offers the registrars an opportunity that only increases the brewing rivalry between Fredrik and Dom. When Fredrik inadvertently learns her secret, Nina must decide if she can trust him.

Oliver's high hopes to resurrect his research project are dashed when a face from the past arrives as the new consultant neurosurgeon, carrying with her a research proposal of her own. When his patient requires a neuro consultation, Oliver is forced to work with his rival, unearthing painful memories of his late wife Tara.

After transferring to AAU, Lofty struggles to find his place on the busier ward. His meticulous approach to treating a notorious patient clashes with a recently promoted and overstretched Morven. Can Lofty convince Morven to slow down and remember why she became a doctor in the first place?