Nick Jordan & Karen Newburn race to find a donor for a young girl cystic fibrosis patient who needs heart & lung transplant surgery. Meanwhile, the prospect of the Christmas party hangs heavy over Darwin ward.

Mike Barratt arrives back in Holby City to run Keller Ward, a new general surgery ward. His team are thrown in at the deep end when they are forced to choose between saving the guilty or the innocent after a racist attack.