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Fletch is shocked when someone from his past walks back into his life. Hanssen attempts to express his feelings to Roxanna. Serena and Ric decide to teach Nicky and Meena a little humility.
Jac is back on form after her surgery and determined to prove she is a doctor not a patient. Dom and Lofty find themselves at cross purposes, which puts their future in the balance. Essie sees Holby afresh through the eyes of a fellow patient.
While trying to help a secretive patient get the care he desperately needs, Fletch's attention is divided by Evie demanding he let her see her grandad. But with so many years of bitter disappointment between them, can Fletch really afford to welcome Steven back with open arms?
Essie receives news about her cancer, calling into question her future at Holby. Determined to help fellow patient Julie and her son Josh, Essie must turn once again to Gaskell for answers.
Dominic fears for his compatibility with Lofty after a contagious incident on AAU shows they aren't on the same page.