Torn between a chance to make history and her conscience, Roxanna faces a tough decision. Will she cross the line?

Hanssen's recovery is put to the test with Essie's arrival, but he'll have to overcome painful memories if he wants to save her life.

When Donna's hopes for her family seem out of reach, Zav is the last person she expects to save the day - has she misjudged him?

Jac is back on form after her surgery and determined to prove she is a doctor not a patient. Dom and Lofty find themselves at cross purposes, which puts their future in the balance. Essie sees Holby afresh through the eyes of a fellow patient.