Ric agrees to undergo the dangerous brain surgery proposed by neurosurgeon Max. During the procedure, Ric has visions of his dead son and lost love, who present him with a terrible choice between life and death. A pregnant Helen returns to Holby, and Dom tries to support Lofty as he faces the prospect of fatherhood.

In Holby City's 1,000th episode, a familiar face returns for the hospital's 150th anniversary. Ric is discharged, but is this the last Holby will see of him? Jac performs a milestone heart-transplant procedure, while the hospital celebrates it's 150th birthday with a bonfire party.