In Holby City's 1,000th episode, a familiar face returns for the hospital's 150th anniversary. Ric is discharged, but is this the last Holby will see of him? Jac performs a milestone heart-transplant procedure, while the hospital celebrates it's 150th birthday with a bonfire party.

A heartbroken Lofty and Helen are rocked by tragic news which tears their world apart. A guilty Xavier evaluates his working relationship with Donna, and are the cards stacked against Jac at Darwin's mortality and morbidity review?