Ric clashes with Max when his determination to destroy Guy puts his health at risk. Distressed by Frankie's disappearance, Essie's suspicions are raised when Sacha avoids the subject. Chloe struggles to keep things professional when her dating life spills onto the ward.

After brain surgery, Ric wakes to find that the world around him has completely changed and that Holby is gripped by a coronavirus pandemic.