A serious road accident involving a motorbike cuts short the bus journey to work for Jasmine Hopkins & Julie Fitzjohn. Meanwhile, back at Holby City, new cardio-thoracic surgeon Alex Adams and new junior nurse Sandy Harper are immersed in a struggle to cope with the chaos caused by an infection scare.

When a well-known hospital fundraiser, John Wooldridge, demands a risky operation, Mike Barratt has to decide whether to refuse, or bow to management pressure.