Eisuke has been missing since the winter break after he found a clue of the whereabouts of a member of his father's company. Coincidentally, the member is at Haido Central Hospital, where Rena Mizunashi is secretly held at. Conan meets with Jodie who confirms Eisuke has been seen at the hospital and reveals that Eisuke's father was a secret CIA agent who died four years ago by the hands of Rena. Conan follows Jodie to the hospital to search for Eisuke and begins to believe Eisuke might be in trouble because the member of his father's company is really a member of the black organization. Conan talks to a nurse to discover there's a patient in the hospital who is also looking for Rena.

Rikumichi Kusuda, the fake patient who the FBI is spying on, sneaks into the nurse's office and takes pictures of the list patients. He is caught by a nurse and the FBI deploy. Rikumichi unravels the bandages around his neck to reveal he has C-4 explosives and makes a getaway in a car. Akai follows him with Conan who was hiding in the back, but the chase is cut short when Rikumichi shoots himself. Conan broke Rikumichi's cell phone prior to the escape, but it's too late, the Black Organization already knows where Rena lies. Back in Rena's room, Eisuke walks in demanding her to wake up and tell him where his sister is. Just as Eisuke is about to stab her with scissors, Rena grabs his hand.