The John F. Kennedy Center for the Performing Arts presented the 26th Mark Twain Prize for American Humor to Conan O'Brien on March 23, 2025 in the Concert Hall. The Prize, which is named to honor one of the world's greatest humorists, was awarded at a gala performance featuring some of the biggest names in comedy, including Bill Burr, Stephen Colbert, Sean Evans, Nikki Glaser, Will Ferrell, David Letterman, Kumail Nanjini, Tracy Morgan, John Mulaney, Adam Sandler, Andy Richter, Reggie Watts, Sarah Silverman, and music director Max Weinberg.