The evil Vaglass organization attacks the city's giant energy source known as the Enetron. Ryuji, the Blue Buster, and Yoko, the Yellow Buster, fight back their forces, but when they summon the giant robot known as a Megazord, another Go-Buster appears, Hiromu Sakurada, the Red Buster.

The Go-Busters infiltrate a hospital where Vaglass has taken hostages in their attempt to acquire Enetron.