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The clock is ticking for the team to locate baby Ana. Sara worries about her young undercover detective Bitsy Sussman. William Randolph Hearst hosts a lavish ball celebrating his goddaughter Violet's engagement to Moore.
All is not what it seems at the Lying-In Hospital as Sara persuades a young nurse to disclose what happens behind closed doors. Kreizler is convinced that hypnosis might unlock the traumatic memories of Senora Linares.
After the horrific murder of a Lying-In Hospital employee, the team are now hot on the heels of the murderer. Sara enlists the help of Joanna to tail their prime suspect. Sara, Kreizler and Moore try and put the pieces together, but they find that not even Sara's office is out of the killer's reach.
Having opened her private detective agency, Sara reunites with Dr. Kreizler, the formidable alienist, and John Moore, now a New York Times reporter, to find the Spanish Consular's kidnapped infant daughter. Their investigation leads them down a sinister path of murder and deceit, heading towards a dangerous and elusive killer. The series shines a light on the provocative issues of the era – the corruption of institutions, income inequality, yellow press sensationalism, and the role of women in society.