In Coyote Wells to deliver some cattle, the Virginian, Trampas and Steve Hill encounter Martin Reese (David Wayne). Reese had lost his wife and children to smallpox, had sold his farm, and now travels giving lectures urging vegetarianism. His lectures are not received well in cattle country and when one of his hecklers is found murdered, Reese is the main suspect, is seen as a murderous loony and is pursued by a posse. On the way back to Medicine Bow the Shiloh cowboys encounter a woman, Ellen Beecher (Barbara Barrie), who knows of Reese's whereabouts. Ellen has several orphans in her care and the Virginian and crew become involved in trying to help Ellen with the children and in finding and protecting Reese from the vengeful posse.

A con man, William Martin (Steve Forrest), and his gang come to Medicine Bow and Martin begins wooing bank teller Lydia Turner (Bethel Leslie) the daughter of the bank's owner. He plans to use the woman to get her father and Judge Garth to invest in a fake oil drilling scheme. However, complications ensue when there is a run on the bank and Martin discovers he likes Lydia.