Major Adams allows two stowaways, Tobias Jones and his young friend Midge, to stay with the train. But Tobias is in trouble due to his drinking, and things get worse when he's accused of murder.

Concerned about Bart Grover, one of the passengers on the wagon train, woman doctor Carol Ames Willoughby tries to help even though she's hampered further by everyone else who shuns her. Meantime an Indian chief needs doctoring and they don't believe in female medicine men.