Doctor Tenma is a brilliant Japanese neurosurgeon who works at Eisler Memorial Hospital in Germany. He is doing well professionally and is even engaged to the director's daughter, Eva. One day, a boy with a gunshot wound to the head is brought to him.

The three doctors are found dead, while the twins are reported missing. Tenma becomes a prime suspect for the murder. The chairman reinstates Tenma as the chief surgeon. Nine years later, a suspect in Lunge's robbery investigation is operated by Tenma and can only say one sentence after waking up.