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Baretta has to go on the run to clear his name after he's framed for the murder of a gun dealer he was investigating, who was selling weapons to teenagers.
Baretta comes to suspect that his close friend, a music store owner, may not only be a drug dealer but may be unknowingly selling heroin so pure that it's killing his customers.
Baretta must use his wits to survive after he and a runaway girl he apprehended unwittingly get into a police car being driven by a couple of holdup men disguised as cops.