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James finds that long hours and rough conditions can make a veterinary work a dog's life, but some dogs, like Mrs. Pumphrey's Tricki-Wu, have it so well that they can afford to spread the wealth.
Life for a newly qualified vet like James Herriot is not at all easy. He travels all the way to Darrowby, Yorkshire to secure a job, but by the time his prospective employer, Siegfried Farnon, turns up for the interview, James has fallen asleep!
Sigfried declares that the business is in shambles financially, and his solution is Miss Harbottle, a meticulous secretary who rules the cash box with an iron hand. Amid a relentless succession of new faces - many gruff, some eccentric - James meets the lovely Helen Alderson.