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A field trip to the center of the sun takes a dangerous detour when the school's safety-conscious principal, Mr. Ruhle, tags along.
The bus takes Ms. Frizzle and the class deep inside Arnold's cousin Janet to learn why our genes makes us look, act and feel the way we do.
The Magic School Bus kids blast into orbit - and onto the International Space Station - only to find themselves on the run from a giant tardigrade.