At the Consistory, Carafa announces King Ferrante of Naples is dead. The Cardinals debate the rightful ruler of Naples: Ferrante's son, Prince Alfonso d'Aragona or King Charles of France. Cardinal della Rovere argues in favor of Charles, despite Rodrigo's new ties to Alfonso. The Consistory concludes, as Della Rovere leaves to inform King Charles of Rodrigo's plans to study both claims.

As Giulia gives birth, Rodrigo and the remaining Cardinals discuss the state of war. Della Rovere is poised to take over as pope. Switching strategies, Rodrigo gives Charles permission to pass through Rome.