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When Rodrigo has a man executed for his homosexuality, Della Rovere comes up with a perfidious scheme to eliminate Rodrigo's secretary, Gacet.
Rodrigo Borgia, Pope Alexander XI, is not yet over the loss of his son, Juan. His powers are threatening to slip from his hands.
By the end of Lent, torrential rains have flooded Rome. Furthermore, the ordinary people feel threatened by a mythical creature with a mule's head.