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Under the influence of poison, Rodrigo suffers from hallucinations and embarrasses himself in public, so he elects to undergo withdrawal treatment.
Rodrigo has to rely on his secretary, Gacet, more than ever. In order to end Rodrigo's papacy, Della Rovere wants to procure a compromising document.
The Pope is attacked during a public morality play and his outraged cardinals assume that the House of Borgia's alliance with France is the cause.