Bull and Izzy experience marital discord when Bull has TAC lead the defense for Diana Lindsay, his ex-girlfriend who's accused of killing her lover's wife. Also, personal conflicts abound for the TAC team when Chunk finds himself defending Diana in court against his boyfriend and prosecutor, Robert.

Bull puts aside his personal grievances to help AUSA Reilly, who prosecuted him for jury tampering, bring one of the world's most dangerous drug lords to justice. As the pair enter into a hesitant partnership, Bull's unconventional style clashes with the lawyer's commitment to working by the book.