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Jack is caught in a dilemma when he has to tell his best friends that Chloe has cancer, and his relationship with Beth continues to deteriorate.
The three doctors fall out when a Consultant refuses to operate on their heart patient because he is a heavy smoker. Meanwhile Will's marriage suffers another setback.
Jack has to deal with a patient whose employer will not let her rest. Meanwhile, Isabel and Ken's romance takes a dive when their ward collapses.