When Red Rock finally opens the doors to its new neurosurgery center and Nic is forced to work alongside Cain again, she, along with the rest of the staff, discover that the center is not everything that was promised. Mina and The Raptor work together with a new surgeon on a heart transplant that has an unexpected result. Meanwhile, after becoming personally involved, Bell asks Conrad to re-examine the three patients who may have been poisoned.

A renowned pediatric surgeon is called over to Chastain for an extremely difficult surgery on a newborn, but when she arrives, The Raptor and Devon realize she is not fit for surgery, resulting in a situation more complicated than they could have imagined. Meanwhile, a Dolly Parton drag queen is admitted to the ER after collapsing on stage, leading Bell and Ezra to a potentially life-saving discovery. Also, Nic and Conrad suspect their patient may be the victim of sex trafficking and Nadine delivers some surprising news to Devon.