A case turns personal for Conrad when the donor recipient of Nic's heart is admitted to the ER. Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision. Meanwhile, the Raptor asks Devon to include his ailing mother in his clinical trial, causing Devon to face a major dilemma.

A tragic accident occurs at Jessica's sister's gender reveal party, putting her brother-in-law's life in jeopardy. Meanwhile, Conrad, Irving & Trevor work on an influencer whose life was put in danger by a risky cosmetic surgery. Then, Bell is cleared for his first surgery back and Billie is forced to face her past head-on.