Dr. Shaun Murphy, Dr. Morgan Reznick and Dr. Audrey Lim treat a woman with autism and a delicate brain condition while navigating the complicated relationship she has with her roommate, who is also on the spectrum. Meanwhile, Lea and Shaun are still figuring out their friendship and roommate status.

Shaun's blunt honesty with a distraught mother of a critically ill newborn baby causes the new chief of surgery to question keeping him on as a resident.