As a conspiracy theorist questions Dr. Neil Melendez's of his liver damage, Dr. Claire Brown treats a woman whose inability to feel pain is threatening both her marriage and her life. Meanwhile, Dr. Shaun Murphy and Dr. Aaron Glassman each face crises in their romantic relationships.

While performing his first solo surgery, Dr. Shaun Murphy alienates a nurse, which puts his residency in jeopardy; Dr. Neil Melendez disagrees with Dr. Audrey Lim on a risky surgery; Dr. Claire Brown spirals into self-destructive behaviors.