Dr. Shaun Murphy treats a patient with an illness that is not only unpredictable in nature, but also unlike anything he or the team at San Jose St. Bonaventure has ever seen before. As safety protocols and quarantines increase due to the global pandemic, Lea and Shaun's new relationship will become tested; and Dr. Alex Park gets ready to move back to Phoenix, Arizona, to be closer to his family. Meanwhile, Dr. Morgan Reznick navigates her way around the clinic following her departure from the surgery team and unknowingly puts herself and several members of the staff in danger. Finally, Dr. Claire Brown continues to work through her grief, still reeling from the sudden death of Dr. Neil Melendez.

With several candidates vying for residency at St. Bonaventure, Chief of Surgery Dr. Audrey Lim tasks Dr. Shaun Murphy, Dr. Claire Browne and Dr. Alex Park with mentoring the top first-year resident contenders. As their mentees shadow them for the day, Shaun and Park meet with Andrews to discuss a difficult surgery scheduled for a minor. Later, Shaun inadvertently insults Lea while discussing the pros and cons of the controversial surgery. And elsewhere, Dr. Morgan Reznick seeks out Claire and Lim's help on a consult.