Shaun and Lea's upcoming engagement party has everyone in a festive mood after their return from Guatemala. Meanwhile, a young single mother learns her son may have contracted his cancer from a surprising source, and Mateo finds out if his previous issues in America will be resolved.

Shaun confronts Salen about the many changes she has implemented since coming on at St. Bonaventure; Glassman is forced to accept his new role at the hospital.