The brain is the most complex organ in the human body. It produces our every thought, action, memory, feeling and experience of the world. But what happens when the brain goes wrong? Jonathan gets an MRI scan to reveal the structure and activity in his brain, and then meets 2FM DJ Rick O'Shea who has been living with epilepsy since he was a teenager. Aoibhinn finds out about the first study to link deterioration of parts of the brain with structural changes in patient DNA and gene activity, and Kathriona visits the RCSI Brain Bank to find out how brain donation is crucial to furthering our understanding of brain diseases.

An alarming number of people are knowingly or otherwise abusing over the counter pain medications. Could there be another way? Aoibhinn and Jonathan take each on in a pain-off (!) and test whether a technique known as transcranial direct current stimulation could increase their pain thresholds. Meanwhile Kathriona finds out what it's like to live with chronic pain, discovers some fascinating and perhaps unexpected benefits of placebos, and meets researchers who are trying to capitalise on the naturally produced cannabis-like chemicals in our own body to help relieve pain.