The team is on the case when a suburban couple is murdered and all forensic evidence points to the home's previous owner, who is currently serving 10 years in federal prison. Meanwhile, OA reunites with an old military colleague, and Scola tries to welcome a new partner.

When the sister of FBI Behavioral Analysis Unit (BAU) profiler Sydney Ortiz is the victim of an attempted kidnapping and sexual assault, Sydney seeks help from Isobel and the team in tracking down a meticulous serial offender who leaves no evidence behind.