When the sister of FBI Behavioral Analysis Unit (BAU) profiler Sydney Ortiz is the victim of an attempted kidnapping and sexual assault, Sydney seeks help from Isobel and the team in tracking down a meticulous serial offender who leaves no evidence behind.

The team is called in to track down a serial killer after the bodies of multiple women with the same physical description are found scattered across the city. Meanwhile, Maggie juggles her roles as a guardian to Ella and an FBI agent.