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Sam and Dean check out rumors of a Crossroad Demon that will give a supplicant their heart's desire... in return for their soul.
Dean remembers an early case involving Sam's elementary school teacher, when the Winchesters were trying to settle down between their monster-hunting trips.
In East St. Louis, Sam and Dean try to help Danny and Jake, brothers who have also fallen under the influence of the Yellow-Eyed Demon.