With the hospital on lockdown after the patients from Rikers escape from their beds, Helen and Max find themselves in a situation that could cost them their lives. Meanwhile, Bloom must put aside her pain to help a patient in need, and Iggy is forced to come to terms with the issues in his marriage.

Sharpe has an important realization that will affect her career. Meanwhile, Max and Reynolds take on uncharted waters when a young patient comes to New Amsterdam with symptoms of a heart attack.