Cardiac surgeon Amit Modi takes on the case of 70-year-old grandmother Jeanette, who has a diseased aorta (the body's largest artery) which is threatening to rupture. A highly complex surgery is needed to save her life. Meanwhile, spinal surgeons Chris Dare and Steve McGillion's patient has conditions so challenging they need to operate for over 20 hours across two days to try to give him a better quality of life.