As the team gathers for a Friendsgiving celebration at Dean's, a violent windstorm touches down in Seattle. As the storm picks up speed, creating dangerous fire conditions, the crew must put the festivities on hold and report for duty, leaving some of them in a life-threatening situation.

When Andy, Maya and Dean respond to a call, they find an injured woman with amnesia; but soon into the treatment process, they realize there is much more to her story. Meanwhile, Captain Sullivan takes Ben and Jack on a house call that quickly becomes a close call for the patient they're treating, while Ryan may not have seen the last of his father, Greg.