Valentine's mental health issues put up obstacles as she navigates male-to-female gender-reassignment, Vera is worried her sore shoulder may be because of a cancerous tumour and David needs advice about some facial pain, and how to light a gas oven safely!

The GPs make some potentially worrying discoveries among their patients who include a woman who has a heart murmur which could indicate something very serious, a young woman who has a worrying lump in her neck and a man who has traces of blood in his stools.