Aaron has developed a mysterious dent in the middle of his forehead, Megan falls asleep in school classes, Mohammed injured his shoulder in a road incident, Mary wants to make sure her heart is okay, and Ellie inherited her mother's psoriasis.

Among a number of patients consulting the doctors about their chronic pain issues are a 32-year-old single mum with a bowel problem caused by a surgical error, a woman whose symptoms include memory loss and painful swelling and a man suffering from ulcerated legs who uses clingfilm to keep his bedsheets clean.