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The last episode finds things mirroring the first episode, when Chatsworth tempts Dobie to join him in a scheme to win a raffle.
With help from some special musk hair oil, Maynard becomes the object of every woman's affections, and as usual, Herbert looks for a way to make money off of this latest development.
So that Dobie can marry her little sister, the Gillises do a makeover on Professor Imogene Burkhart.
Maynard helps his special friend, the talented Emily Klauber, find success as singer Kitty Fontaine.
The Gillis family gets caught up in espionage when Russian spies mistake Maynard for a leading scientist.
Maynard, fueled by special energy pills, becomes a boxer, with Herbert T. Gillis as his manager.
Can Dobie, er, will Dobie stop the wedding of Zelda and Maynard?
Dobie and Herbert plot against each other in their attempt to rescue a starlet's lost dog. Herbert wants the reward money. Dobie wants Valentine Van Loon's undying gratitude. Maynard just wants to pal around with the dog.
Sleepwalking Maynard is accused of stealing Mrs. Osborne's jewelry.
In the Latin American country of Boca Dulce, Maynard is forced to stand in for his lookalike, General Ramon, also known as "El Tigre".
Chatsworth moves in with the Gillis family, and Herbert caters to his every whim, hoping Chatsworth will reward him with big money...someday.
Maynard tries to save a chimpanzee from a medical research laboratory. The only way to do this is to teach him tricks, but the chimp seems to have no talent.
A freak accident turns Maynard into a robot, but not just any robot. This machine can make hit records, something cousin Virgil intends to take full advantage of.
When the Osbornes lose all their money, Chatsworth tricks Maynard into collecting donations for them. Then Chatsworth and his mother decide to become butler and maid to the Gillis household.
Dobie must choose between Zelda and the glamorous Claypoole, even though Zelda no longer seems to want him.
When Maynard and Herbert get caught together in a novelty item called a "Gypsy Love Link", Maynard must pretend to be Herbert's wife when he attends a grocers' convention.
Dobie is unfaithful to Zelda yet again, this time with an eccentric, European girl who wants to dance with him in the moonlight. Soon, this Anastasia has everyone dancing!
Mistaking Dobie for Chatsworth, a failed millionaire hypnotizes him into marrying his daughter.
When Dobie becomes campus DJ, Zelda wants him to play her new song, and so does "folk" singer Prudence Virtue. Prudence's manager even offers money and gifts. Will Dobie be able to resist the temptation of payola?
A wanted criminal takes the Gillis family hostage.
Maynard wants to join the famous musical act, the Lettermen, but they want Dobie instead. Will Dobie betray his friend for fame and romance?
Cousin Virgil rides back into town, using his Southern charm to steal Dobie's job and his girl.
A grown-up opera singer wants to marry sixteen-year old Duncan, but her jealous, passionate lover stands in the way, and he has no qualms about killing Duncan.
When they find out Maynard, age 21, still believes in Santa Claus, the Gillises plot a way to disillusion him.
When Maynard drinks some experimental chemicals, he turns into a monster.
Maynard and Duncan mistakenly believe they've killed Herbert, and run away. Because Duncan is missing, Dobie and Herbert are accused of killing him.
Dobie comes up with a new way of cheating on a test--getting a talkative mynah bird to memorize and repeat all the answers!
Duncan almost puts Herbert out of business because of a pretty thing and her big sister (whom Dobie digs).
Dobie has never shied away from lying to win a girl's affections, but this time he has sunk to a new low: telling a med student that he has six months to live. If that isn't bad enough, the lie is also believed to be truth by Maynard and Dobie's parents.
All of Central City is in danger when Maynard and Duncan unknowingly drive off with a tank of nitro glycerin.
Dobie joins the football team to impress a cheerleader, but her boyfriend, "Roadblock" Jahurski, threatens to send Dobie to the hospital.
Just when Herbert thought he'd get some peace and quiet around his home, what with Dobie having grown up, his teenage nephew Duncan moves in. He's as girl crazy as Dobie, and what's worse, Dobie is teaching his cousin his ways--namely, getting girls through lying.
Dr. Burkhart takes her anthropology class, including Dobie, Maynard, and Dobie's latest love interest, on a trip to the Amazon. But things take a dark turn when Dobie is accused of jealously murdering Maynard and shrinking his head.
Cousin Virgil T. Gillis has plenty of Southern charm, and loves to flatter. In fact, he charms everyone out of their time and money, except for Maynard, who knows he's a sneak.
Paranoid Dobie believes his friends and his family are all out to murder him.
When Maynard gets institutionalized due to his misunderstood mental health, Dobie pretends to be Ben Casey to break him out.