Monroe is busy pursuing Lizzie and counseling Shepherd when an awkward, violent woman arrives at St. Matthew's with a deadly crebral aneurysm. The neurosurgeon calls on Bremner to help save her life.

Nick's stag party is ruined when a lethal traffic accident brings the whole team into the hospital. While the hospital's facilities are stretched to the breaking point, Bremner and Shepherd reach an agonizing crossroads in their relationship.