When Hoss catches spring fever, it takes a little old lady named "Looney" to help cure him.

Little Joe struggles with his conscience, trying to believe that his friend, Seth Pruitt, did the right thing after Seth admits to the mercy-killing of his fiancée's father when the man was in agony from a broken back and begging for death.

Ben finds Hoss in the barn waiting for a mare to give birth. Ben can't help but remember that's how Hoss' mother (Inger) was. He then finds an old journal wherein he wrote down their trek West. While Hoss waits, Ben reads it and recalls how their trek was arduous. And Inger was pregnant with Hoss and they had to deal with Indians and a drunken wagon master.

A girl (Stefanie Powers) named Cal causes chaos on the Ponderosa and leads Little Joe into a confrontation with Doc Holliday. Trouble with a capital "T" that rhymes with "C" comes to Virginia City when Little Joe brings young Calamity Jane home to the Ponderosa after rescuing her from a deadly prairie raid.