As the fierce battle draws to an end, Tanjiro and Uzui behead Gyutaro just as Zenitsu and Inosuke behead Daki. But then, Gyutaro unleashes a devastating Blood Demon Art, burying the city in rubble. When Tanjiro awakens, he joins Nezuko and Zenitsu, only to find Inosuke and Uzui on the brink of death from Gyutaro's poison...

Amid the wreckage from the buildings destroyed by the destructive attacks of Daki's Belt, Tanjiro awakens. Zenitsu is trapped under the rubble and Inosuke has been impaled by Gyutaro's scythe, while Uzui has lost an arm and his heart has stopped. As Gyutaro taunts Tanjiro by calling him a disgrace, all seems hopeless until...

Hinatsuru's use of wisteria poison leaves Gyutaro momentarily vulnerable, but Tanjiro and Uzui's attacks fall just short. Using his Blood Demon Art, Gyutaro vanishes from Uzui's sight only to reappear assaulting Hinatsuru. Tanjiro and Uzui attempt to save her, but they are thwarted by Daki's Belt.

Uzui battles furiously, taking on both Daki and the other demon who emerged from her body, Gyutaro. But he's gradually losing strength due to the poison from Gyutaro's scythe. Just then, Inosuke, the sleeping Zenitsu, and Tanjiro, who's managed to get Nezuko to sleep, all come rushing to Uzui's aid...

As Nezuko rushes to aid Tanjiro during a critical moment, her appearance begins to gradually take on a demon form as she sustains Daki's attacks. Nezuko is able to overpower Daki as her demon form accelerates; however, she turns her attention to innocent bystanders injured during the battle and charges towards them. While Tanjiro attempts to restrain Nezuko, Daki draws near...

Furious at Daki's disregard for lives, Tanjiro angrily confronts her, causing her to experience Muzan's memories of an old enemy. His excessive use of Hinokami Kagura soon brings him to his knees in pain.

Facing Daki alone, Tanjiro tries to use Hinokami Kagura but is hampered by the extreme stress it causes his body. Inosuke and Tengen locate the demon's victims and meet the demon responsible for abducting Zenitsu and his wives. 

Realizing Zenitsu is now missing, Tanjiro and Inosuke re-arm and look for signs of the demon. Tanjiro goes in alone and is confronted by Upper Rank Six. 

After arriving at the Entertainment District, Tanjiro and his comrades infiltrate each House where Uzui's wives, Suma, Makio and Hinatsuru, work. While working as apprentices and searching for their whereabouts, Inosuke hears that Makio has been shutting herself away from everyone in her room.

One day, Tanjiro returns to the Butterfly Mansion and finds Sound Hashira, Tengen Uzui, attempting to take Aoi and Naho away on a mission against their will. Tanjiro, Zenitsu and Inosuke offer to go on that mission instead, and they head to their next destination - the Entertainment District.

After the Mugen Train incident, Akaza visits Muzan Kibutsuji. Guided by a crow, Tanjiro Kamado heads off to the Rengoku residence to convey Kyojuro Rengoku's last messages to his father and little brother. Tanjiro's group return to the Butterfly Mansion.

Akaza continues to offer Rengoku the chance to become a demon to improve his skills. Rengoku refuses his offer and is trying his best to keep up with him. The fire Hashira has one goal:to protect his comrades even if it costs his own life.

Tanjiro has finally slashed Enmu's neck with the help of Inosuke. The tremors from the train flipped it over the rails. As silence deepens a mysterious figure approaches from behind.

The battle with Enmu continues as Inosuke, Zenitsu and Rengoku awaken from the spell. Tanjiro and Inosuke try to pinpoint the demon's weak spot, while the others focus on protecting the passengers in the train.

With Tanjiro successfully awakening from his dream, he confronts the demon responsible, Lower One Enmu. But the situation challenges Tanjiro's resolve when Enmu proves more powerful that any demon he's ever faced.

Trapped in Enmu's spell, Tanjiro, Zenitsu, Inosuke and Kyojuro fall closer and deeper into an eternal slumber. Faced with death, Tanjiro is forced to confront his demons to save them.

Kyojuro Rengoku heads to the Mugen Train to investigate the disappearance of over forty passengers and encounters a demon along the way. After saving the people attacked by the demon, he finally arrives at the Mugen Train. What lies ahead of him?

Flame Hashira Kyojuro Rengoku receives new orders: Travel to the Mugen Train, where over forty people have gone missing, and conduct an investigation. Leaving the Demon Slayer Corps Headquarters, he sets off on this new mission.