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The drovers are reunited with their former scout, Pete Nolan, who is trying to deal with Wild Horse, an Indian who has gone renegade and is attacking the horses that Pete is escorting to General Augustus Perry.
The men are forced to turn to a female doctor for help when one of their own is injured. However, the hands don't trust her, and a local quack is trying to run her out of town.
Rowdy is lured to a house where several other strangers are trapped. They are all locked up together, and someone starts killing them one by one.