The drovers arrive outside of Abilene, but an outbreak of smallpox threatens to keep them from ever entering the town.

Favor has to deal with another trail boss whose herd has ticks, and threatens to spread the ticks to Favor's cows.

A demented gold miner holds the drovers prisoner in a ghost town in the hopes that they'll help him--and his three equally captive daughters--mine the gold that he has convinced himself exists.

Rowdy is lured to a house where several other strangers are trapped. They are all locked up together, and someone starts killing them one by one.

The drovers are reunited with their former scout, Pete Nolan, who is trying to deal with Wild Horse, an Indian who has gone renegade and is attacking the horses that Pete is escorting to General Augustus Perry.

The men are forced to turn to a female doctor for help when one of their own is injured. However, the hands don't trust her, and a local quack is trying to run her out of town.

Mushy gets involved in a family squabble when his cousin asks him to deliver her sister to their mother. Problem is, the sister wants to pursue a career as a saloon girl, and doesn't want to go.

A German count takes three of the drovers prisoner and puts them to work as his servants.

A military officer discovers that one of the Indians that he despises... is his wife.

The drovers save a pitchman, George Stimson, at the cost of one man's life. However, when they try to raise money for the dead man's family, George's ideas end up backfiring.

A con man, Bateman, dresses up as Santa Claus and tries to convince the drovers that his son is dying so that they'll offer valuable presents.